Ventolin HFA (Albuterol Sulfate Inhalation Aerosol) for Asthma

MAIN INFORMATION

Ventolin Definition

  • Name: Ventolin HFA (Albuterol Sulfate Inhalation Aerosol) / Salbutamol
  • Active ingredient: Albuterol sulfate
  • Used for: Asthma
  • Dosages (mcg): 100
  • Drug Class: Bronchodilator

CONTENT

  1. Ventolin Definition
  2. Ventolin Applications
  3. Contraindications: Is Ventolin Right for Me?
  4. Health Effects and Benefits
  5. Possible Ventolin Side-Effects
  6. Food and Drug Interactions
  7. List of Medicines the Combination with Which is Dangerous
  8. Safety Note on Ventolin
  9. Storage Requirements
  10. Ventolin Full List of Ingredients
  11. Customers Questions about Ventolin

Ventolin Definition


Ventolin is a medicinal agent for acute asthmatic attacks and other inversive diseases with bronchial obstruction. Ventolin falls into the group of short-acting selective adrenoceptor agonists. Its active substance, salbutamol has antiallergic action. While interacting with bronchus receptors, it causes their expansion and thus, saves life during asthmatic attack. Introduction of solution for inhaling via nebulizer provides maximal penetration into lower segment of respiratory apparatus.  Literally in 5 minutes after the result is shown, endurance of action remains up to 6 hours after the procedure.

It is issued in form of nebulas (plastic ampoules) with the volume of 2,5ml which is equal to 2,5mg of salbutamol. The drug is widely used to relieve rapidly the symptoms of bronchial allergy and bronchial obstruction, to treat non-productive cough, to dilute expectorations during A.R.V.I. or complication of pertussis.

Ventolin Applications

Therapeutic indications:

  1. Bronchial allergy:
  2. Rapid relief of bronchial allergy symptoms, including acute asthmatic attack;
  3. Prevention from bronchial spasm, connected with allergen influence or resulted from physical exertion;
  4. Application in form of one of the components while long-lasting treatment of bronchial allergy.
  5. Chronic obstructive pulmonary disease, accompanied by inversive respiratory obstruction, including chronic bronchitis and pulmonary emphysema.

Ventolin Contraindications: Is Ventolin Right for Me?

Ventolin is distinguished by the following contraindications:

  1. Hypersensibility to any of the components of the drug;
  2. Premature delivery;
  3. Threatened abortion;
  4. Pediatric use (up to two years).

Ventolin should be taken with care:

  1. by patients suffering from tachy-arrhythmia, myocarditis, heart diseases, aortic stenosis, coronary artery disease, chronic cardiac insufficiency, arterial hypertension, thyrotoxicosis, pheochromocytoma, decompensated diabetes mellitus, glaucoma, nephritic or hepatic impairment.
  2. if combined with unselective beta-adrenergic blocking agents.
  3. during pregnancy.
  4. during lactation period.

Patients should be instructed on how to use correctly Ventolin inhaler. Bronchodilators must not be the only and one-of-kind components of bronchial allergy of unstable and hard treatment. If a normal dose of Ventolin becomes less efficient and of shorter duration (drug’s action should last not less than 3 hours), a patient must consult a doctor.

Increase of demand of inhalative beta2-adrenergic receptor agonist shows acute exacerbation of a disease. In these cases, a doctor must reassess a plan of patient’s care. Sudden and progressive deterioration of bronchial allergy may constitute a threat for patient’s life. Therefore, in these circumstances it is required to consider assignment or dose enhancement of glucocorticosteroids immediately. Such patients are recommended to conduct daily monitoring of peak expiratory flow rate.

Ventolin must be taken with care by patients suffering from thyrotoxicosis. Treatment with beta2-adrenergic receptor agonists (especially in case of their introduction parenterally or by means of nebulizer) may cause hypokalemia. Special attention must be paid to treatment of hard attacks of bronchial allergy, since in these circumstances hypokalemia may enhance as a result of simultaneous intake of xanthine derivatives, glucocorticosteroids, diuretics and following hypoxia as well. These cases require control of potassium level in blood serum.

Ventolin Health Effects and BenefitsVentolin Health Effects and Benefits

Ventolin improves patient’s condition fulfilling the following functions:

  1. Salbutamol is a beta2-adrenergic receptor agonist. In therapeutic dose, it affects beta2-adrenergic receptors of bronchial smooth muscles having insignificant impact or not influencing at all on beta2-adrenergic receptors of myocardia. It renders a conspicuous bronchodilating effect anticipating and liquidating bronchial spasm and decreases obstruction in respiratory tract.
  2. Ventolin enlarges lung pulmonary vital capacity. It increases mucociliary clearance (in case of chronic bronchitis up to 36%), stimulates mucus secretion, activates ciliated epithelium functions.
  3. Ventolin has positive chrono- and inotropic effect, causing expansion of coronary arteries.
  4. Ventolin has a number of metabolical effects: reduced concentration of potassium in blood plasma, influences glycogenolysis and insulin outflow, renders hyperglycemic (especially for patients suffering from bronchial allergy) and lipolytic impact.
  5. After the intake of inhaler, the action is achieved fast – within 5 minutes (maximum in 30-90 minutes) and lasts 4-6 hours.

Possible Ventolin Side-Effects

Salbutamol can cause a light tremor of skeletal muscles which is conspicuous in hands and is a characteristic side-effect of all adrenergic receptor agonists. Very seldom a patient has a headache, distension of peripheric vessels and a slight compensatory increase of heartbeat rate. Very occasionally the reactions of high hypersensitivity (including atrophedema, urticaria fever, bronchial spasm, arterial hypotony, and collapse), muscle cramps and tachycardia may occur.

Inhalers are able to cause paradoxical bronchospasm which should be neutralized by means of another pharmaceutical form of salbutamol or another fast-acting inhalant bronchodilator. In this case the intake of Ventolin must be stopped immediately; a doctor must determine state of a patient, conduct necessary examination and assign a proper therapy. Inhalers may cause irritation of mucous membrane of mouth cavity and pharynx.

Therapy by means of beta-adrenergic blocking agents sometimes may cause hypokalemia which may present a grave danger for a patient. Like other beta-adrenergic blocking agents, salbutamol may cause a psychic excitement and increased physical activity among children. Patients with underlying risk for arrhythmia development may be seriously affected by salbutamol. The latter may cause heart beat disorders including continuous arrhythmia, supra-ventricular tachycardia and premature ventricular contraction.

Ventolin Food and Drug Interactions


Ventolin and alcoholic drinks

Adrenoceptive effects may get enhanced because of adrenaline’s release from medullary area under the influence of alcohol. Thus, increase of diuresis (urine production), characteristic for alcohol may reduce the time of drug’s effect.

Ventolin and food

As Ventolin falls into the group of bronchial spasmolytic, it may be taken regardless the type and time of meal.

Ventolin and other drugs

It is not recommended to take salbutamol combined with unselective beta-adrenoceptor blockers, such as propranolol. Salbutamol is not counter-indicative to the patients taking monoaminooxidase inhibitors (IMAO).

List of Medicines the Combination with Which is Dangerous

Dangerous interactions:

  1. Salbutamol is not recommended along with unselective beta-adrenoceptor blockers, such as propranolol.
  2. In combination with CNS stimulants Ventolin enhances their effect and causes tachycardia for patients suffering from thyrotoxicosis.
  3. Theophyllin and other variants of xanthine along with Ventolin enhance the likelihood of tachy-arrhythmia development; whereas remedy for inhalational anesthesia, levodopa – to severe ventricular arrhythmia.
  4. Simultaneous intake of Ventolin with anticholinergic drugs (including the inhalative ones) may cause an increased intraocular pressure.
  5. Diuretics and glucocorticosteroids enhance hypokalaemic action of salbutamol.

Safety Note on VentolinSafety Note on Ventolin

 Posology and Administration

Ventolin is a metered dose aerosol dedicated only for inhaled administration. Only attending doctor can decide whether it is allowed increasing dose or frequency of drug’s intake or not. It is not recommended to take Ventolin more than 4 timers per day. Need for frequent application and sudden dose titration shows anabasis.

Adults (including elderly patients) should take 100-200µg (1-2 inhalations) for liquidation of bronchial spasm. Prevention of bronchial spasm, connected with allergen action of caused by physical activity requires a dose of 200µg (2 inhalations) 10-15 minutes before initiating agent’s action. Long-term supporting treatment requires optimal dose of 200µg (2 inhalations) 4 times per day.

Children should take 100-200µg (1-2 inhalations) for liquidation of bronchial spasm. Prevention of bronchial spasm, connected with allergen action of caused by physical activity requires a dose of 100-200µg (1-2 inhalations) 10-15 minutes before initiating agent’s action. Long-term supporting treatment requires optimal dose of up to 200µg (2 inhalations) 4 times per day.

Ventolin is not used in form of injections. It should be taken under supervision of experts by means of special inhaler (nebulizer) with mask, T-shaped or endotracheal tube. Ventolin is taken undiluted, although if required of long-term usage of salbutamol solution (more than 10 minutes), the medicine may be diluted by sterile saline solution. For most patients, the therapeutic action of salbutamol lasts 4-6 hours.

Application during pregnancy and lactation

During pregnancy and lactation, the drug is administered only in cases when expected benefit for mother exceeds potential risk for unborn child. Apparently, salbutamol penetrates into maternal milk, therefore it is not recommended for nursing mothers. Nevertheless, it is not known whether salbutamol in maternal milk has adverse effect on new-born child or not.

Overdose

In case of salbutamol overdose the best antidotes are cardioselective beta-adrenergic blocking agents. Nevertheless, beta-adrenergic blocking agents should be taken with care by patients with bronchial spasm attacks in past medical history. Taking of large dose of salbutamol may cause hypokalemia. Thus, at suspicion on overdose one should control potassium level in blood serum.

Ventolin Storage Requirements

Period of validity: 2 years. You must not take Ventolin after shelf-life expiration. Store it in dry cool light-proof place not above 30°С. Keep out of reach of children.

Ventolin Full List of Ingredients

Formulation of Ventolin:

Metered dose aerosol for inhalations contains 100µg of salbutamol in one dose (in form of salbutamol sulphate). Besides, Ventolin consists of tetrafluoroethane (norflurane) which is not related to chloro fluorocarbons. One balloon contains 80 or 200 doses with 100µg each.

Aerosol does not contain Freon (chloro-fluorocarbons CFCs) destroying ozone layer of the atmosphere. Ventolin is free from preserving agents and colorants.

Customers Questions about VentolinCustomers Questions about Ventolin

May Ventolin be used for treatment of bronchial spasms and acute hyperkalemia?

Yes, bronchial spasm and acute hyperkalemia are the most popular variants of Ventolin application. Do not use this drug without preliminary consultation with your attending doctor.

Is it allowed operating heavy industrial equipment during the course of Ventolin?

If you feel drowsiness, vertigo, hypotension or headache after taking Ventolin, you should refuse from driving or operating heavy industrial equipment. You must check the reaction of your organism on Ventolin before taking it.

Does Ventolin cause have addicting property?

Ventolin doesn’t have addicting properties.

Is it safe to use Ventolin during pregnancy or lactation?

During pregnancy and lactation, the drug is administered only in cases when expected benefit for mother exceeds potential risk for unborn child. Apparently, salbutamol penetrates into maternal milk, therefore it is not recommended for nursing mothers. Nevertheless, it is not known whether salbutamol in maternal milk has adverse effect on new-born child or not.

How should I take Ventolin?

Adults (including elderly patients) should take 100-200µg (1-2 inhalations) for liquidation of bronchial spasm. Prevention of bronchial spasm, connected with allergen action of caused by physical activity requires a dose of 200µg (2 inhalations) 10-15 minutes before initiating agent’s action. Long-term supporting treatment requires optimal dose of 200µg (2 inhalations) 4 times per day.