Statins, Viagra and Sexual Function

Connection between medication for cholesterol and erection was examined by American researches. They checked the influence of tablets for decrease of cholesterol level on male sexual health. It was approved that they do not only have adverse impact on erectile functioning, but even improve its work. As of today, statins are considered to be the most important remedy for prevention from heart or apoplectic attack. They are taken by millions men and women. It was proven that statins decrease probability of cardio-vascular disorders. But how do they affect erection? According to eleven research studies concerning statins, it was demonstrated that the intake of drugs for cholesterol causes improvement of erection by 3,5 per cent. It makes one third of analogous indicators achieved by special medicines, such as Viagra. Medical experts explain this effect by the fact that statins like Viagra provide vasodilation and better functioning of vessels.

What are Statins Used for?

Statins

Statins is a group of medicinal products decreasing the level of total cholesterol and LDL cholesterol in blood. Research studies show that they are the best remedies among medications for cholesterol level decrease of low-density lipoproteins as well as triglycerides. Clinical trials demonstrate statins effectiveness in decrease of risk for heart and apoplectic attack (including their relapses), and improvement of patients’ quality of life. Statins are especially popular due to absence of noticeable side-effects which enables to take these remedies for a long time. Besides, safety of this therapy is still under discussion.

It is important that the level of total cholesterol cannot cause statins intake. A patient should be guided by low-density lipoprotein cholesterol. A doctor collates normal level of this substance with indicators of an individual and concludes about worthwhileness of therapy with statins.

The risk group (according to high level of low-density lipoprotein cholesterol) is constituted by people who underwent the following disorders:

  • myocardial infarction;
  • ischemic stroke;
  • effort angina;
  • intermittent claudication;
  • diabetes (1 and 2 type);
  • chronic renal failure;
  • clinical occurrence of atherosclerosis in the past.

Statins decrease production of cholesterol in human organism blocking the action of enzymes which are necessary for its production. Some of these medications are produced of penicillin fungus and Aspergillus terrens (group of natural statins), others are created by means of synthetic method.

Nowadays a number of patients suffering from chronic hepatic disorders especially with metabolic syndrome along with non-alcoholic fatty liver disease or metabolic impairments on the setting of chronic virus hepatitis C need to take statins for prevention against cardiovascular diseases. In this regard, medical experts have to take into account complex mechanisms of statins interaction with hepatic metabolism in these conditions. Prescription of medicines for persons suffering from these disorders may have a serious prognostic meaning.

It is important to know that the first and most essential method for a person with elevated LDL cholesterol must lie not in statins intake, but in change of lifestyle.

The most crucial in this case are two directions:

  1. change of dietary regimen (decrease of the amount of saturated fat and cholesterol in food, increase of amount of unsaturated fat);
  2. increase of the level of aerobic physical activity (fast walk or slow run where each episode of activity would be not less than 10 minutes).

Natural statins may be found in many alimentary products. Their intake is not dangerous with side-effects and adverse impact on liver.

Natural statins are:

  • Cevitamic acid acting as inhibitor in the process of low-density lipoproteins production;
  • Vitamin B3 (niacin) is contained in meat, cereals and milk;
  • Garlic;
  • Turmeric root (curcumine) stimulates processing of cholesterol by liver and clearance of cholesterol surplus from organism;
  • Oatmeal, barley, other cereals;
  • Beans;
  • Carrots;
  • Apples;
  • Avocado;
  • High-fiber berries;
  • Cod liver oil;
  • Flax seeds;
  • Tofu, miso, tempeh and other products of fermented soy.

Statins Available at My Canadian Pharmacy

In order to achieve maximal effect, therapy with statins must be long-term or life-long. Nowadays, there is a variety of statins offered by My Canadian Pharmacy including original drugs and their generics.

There are the following products ranging in accordance with statins types:

1. Lovastatin (daily dose 10-80mg) – natural statin made of Aspergillus terreus:

  • Mevacor;
  • Lovacor;
  • Lovasterol;
  • Liprox;
  • Lovahexal.

2. Pravastatin (daily dose 10-40mg) – semisynthetic statin:

  • Lipostat

3. Simvastatin (daily dose 5-80mg) 0 semisynthetic statin:

  • Zocor;
  • Simvacard;
  • Zosta;
  • Simvahexal;
  • Simgal;
  • Vasilip;
  • Vastatin.

4. Fluvastatin (daily dose 20-80mg) – synthetic statin:

  • Lexol.

5. Atorvastatin (daily dose 10-80mg) – synthetic statin:

  • Liprimar;
  • Atoris;
  • Storvas;
  • Tulip;
  • Torvacard;
  • Torvadac;
  • Astin;
  • Lipidex
  • Lipicor.

6. Rosuvastatin (daily dose 5-40mg) – synthetic statin:

  • Mertenil;
  • Crestor.

Can Statins Improve Erectile Ability?

Short-term course of therapy with statins by men with high level of cholesterol has improved erectile function considerably. It became evident that erectile dysfunction was an indicator of reduction of men’s vascular system resistance and considerable factor of cardiac disorders. It is possible that erectile function gets improved in connection with decrease of low-density lipoproteins in blood or other pleiotropic effects of statins (improvement of endothelium function). One way or another, this meta-analysis shows improvement of erection after conducted therapy course.

According to statistics, around 18-30mln men suffer from erectile dysfunction very often after 40 years of age.

The main factors influencing impairment of erection are as follows:

  • cardio-vascular diseases;
  • enhanced level of cholesterol;
  • high arterial blood pressure;
  • 2 type diabetes;
  • obesity;
  • smoking;
  • depression;
  • stress.

Medical experts have conducted meta-analysis of eleven randomized and placebo-controlled trials oriented to research of statins influence on erectile functioning. 647 men with high level of cholesterol and erectile dysfunction participated in these trials. Men aged 57-59 years in average took statins during 3-8 months. The results have shown that cholesterol level (low-density lipoprotein decreased in target groups from 138 to 91 mg/dL) has not only reduced within this period, but also demonstrated that indicators of potency increased by 24%. Effects of cholesterol level decrease by means of statins were even higher than change of lifestyle or intake of other medicinal products.

Enhancement of erectile function during statins administration made around 1/3-1/2 of that effect which is observed by means of PDE5 inhibitors. This impact is bigger than the effect achieved by change of lifestyle. Men who have to take statins for cholesterol level control; potency boost will be additional advantage. Statins are a two-edged sword: on the one hand they improve endothelium function which enhances blood supply to penis; on the other hand they decrease cholesterol level which is a predecessor of testosterone. Nevertheless, meta-analysis of eleven research studies has shown that positive statins effect prevails. Medical experts believe that due to the results of meta-analysis, men will be ready to be treated for cholesterol level decreases, since nowadays they accept it less than it was prescribed by a doctor.

Can You Take Viagra with Simvastatin?

Can You Take Viagra with Simvastatin?Simvastatin falls into the group of lipid-lowering medications. Simvastatin ranks among statins preventing or completely slowing down the process of HMG-CoA reductase production. Besides, the analyzed remedy is considered to be pro-drug, since its structure contains a locked lactonic ring which is gradually hydrolyzed after it gets in human organism. As per Simvastatin instruction, its lactonic ring is completely identical to some element of HMG-CoA reductase enzyme. Resulting from competitive antagonism, statin molecule gets connected with coenzyme A.

The second component of statin molecule slows down or completely prevents from transformation process of hydroxymethyl glutarate into mevalonate which is in fact an intermediate product in synthesis of cholesterol molecule. Slowing down of HMG-CoA reductase activity results in a lot of reactions. As a result, they considerably decrease cholesterol concentration inside the cells, influence compensational increase of low-density lipoprotein receptors activity, and speed up katabolism of low-density lipoprotein cholesterol. Statins do not take adverse impact on hepatic and lipoprotein lipase, and katabolism or synthesis of free fatty acids. Many medical research studies confirm the fact that Simvastatin is able to increase the level of high density lipoprotein cholesterol up to 14%. Statins take a good impact on vessel walls, increase rheologic capacities of blood, and have antiproliferative and antioxidant capacities while taking lipid-lowering action.

This medication improves endothelium function at the end of incessant therapy course. After Simvastatin intake, patients experience normalization of functioning of cardio-vascular system.

As to Simvastatin’s co-administration with other medicines, this medicine boosts considerably the impact of the latter on human organism. In case this medication is taken with itraconasole, cytostatic agents, fibrates, immunosuppressant drugs and enhanced dose of nicotinic acid, a patient may provoke myopathy development. Combination of Simvastatin along with dioxin causes increase of dioxin concentration in blood plasma. Moreover, as of today, medical practice demonstrates a sole case when a patient took Simvastatin and Viagra which caused rhabdomyolysis occurrence.

Viagra and Other ED Drugs at My Canadian Pharmacy

Erectile dysfunction is unfortunately widely-spread among men especially with the increase of years. Weak erection may become a cause of lack of confidence and psychological trauma for both partners leading to depression, cheating, alcoholism and other undesired circumstances. Nevertheless, My Canadian Pharmacy offers best solutions to solve this uneasy problem. Such modern medications as Viagra, Levitra, Cialis and their generics are very helpful in ED treatment.

Many men prefer to buy alternative medications for potency boost known as generics. My Canadian Pharmacy has in its catalogue Apcalis, Kamagra, Tadadel, Sildenafil, Vardenafil, Sildisoft, Vectra, Vistagra, Tadarise, Vilitra, etc. It’s no secret that the price for branded medications, such as Levitra, Cialis or Viagra is rather high in traditional drug store. If you do not want to spend a lot of money on purchase of expensive brand, generic would be a perfect alternative. Moreover, generic’s efficiency is of the same quality, as the original’s one.

In case you have come across the problems of impotency, weak potency and erection or premature ejaculation, My Canadian Pharmacy is ready to help! Do not panic or sink into a depression. Our online pharmacy will allow you to return happiness of sexual life!