PDE5 inhibitors and Their Role in Erectile Dysfunction Treatment

Viagra, Cialis & LevitraThe effectiveness of the PDE5 inhibitors – like Generic Viagra, Cialis, Levitra offered for customers of My Canadian Pharmacy service – for erectile dysfunction (ED) has been confirmed in numerous studies among various male population groups. My Canadian Pharmacy experts researched and gathered a bunch of interesting facts and study results about the effect provided by PDE inhibitors of the first generation – Cialis (Tadalafil), Viagra (Sildenafil), Levitra (Vardenafil).

Enhanced erections delivered by PDE5 inhibitors are proved multiple times

Sildenafil a.k.a. Viagra, being for the longest time on sale, is logically turned to be the best studied medication. In a randomized double-blind study with 330 males involved (with the average age of 58 years), the doses (flexible ones) of 25, 50 or 100 mg of Sildenafil received according to the schedule. After the regular intake of Sildenafil by a real group of patient (not a placebo one) within twelve weeks there were results of Sildenafil’s prolonged effect – the episodes of erectile dysfunction were significantly reduced to 22.1 compared to 12.2 in a placebo group.

The quality of erectile function was measured by the International Index of Erectile Function questionnaire (IIEF). In addition to firmer and longer erections, other sexual aspects like orgasm or satisfying sexual intercourse were also improved significantly. In the study only the patients with chronic 5-year long ED took part. More than half of the tested patients had erectile dysfunction because of physical causes.

What causes of erectile dysfunction can be beaten with the help of PDE5 inhibitors?

Erectile dysfunction is defined as the ongoing inability (for at least 6 months) to achieve a penile erection sufficient enough for a satisfactory sexual intercourse. Despite the common belief, erectile dysfunction on 62% of cases is caused by more than 1 reason. In addition to the most common physical ED causes, psychogenic factors play the major role. In fact, all factors have to be counted when a doctor diagnoses erectile dysfunction.

Physiological causes that trigger erectile dysfunction can of different kind including – vascular diseases such as hypertension or arteriosclerosis. Dyslipidemias and diabetes can cause the vessels disorders because of this effect. Also depression, multiple sclerosis, spinal cord injury, anatomical malformations and pelvic organs’ surgeries can also provoke the development of erectile dysfunction. Some medical prescribed drugs like thiazides, beta-blockers, SSRIs (selective serotonin reuptake inhibitors) can also cause the episodic forms of erectile dysfunction. In addition, psychogenic triggers are almost always involved as well. Stress, fear of failure and the relationship problems affect a normal penile erection.

Important notice: men with diabetes have a greater risk of developing erectile dysfunction. The vitro studies have shown that the smooth muscles of modified by diabetes vessels are less relaxed than in healthy vessels.

In addition to the high efficacy profile of PDE5 inhibitors helping people with diabetes-related erectile dysfunction, the above mentioned study has also demonstrated Sildenafil’s efficacy for patients with cardiovascular disease, prostate cancer, spinal cord injury, depression, multiple sclerosis and Parkinson’s disease. The studies held in USA, Europe, Latin America, Africa and Asia also revealed the effectiveness in different ethnic groups of tested males from 32 to 58 years old. The identical studies were also later held for Vardenafil and Tadalafil and the results were even better than for males who take the first generation of Sildenafil based pills.

How do PDE5 inhibitors work in a body and help to achieve an erection?

A normal penile erection is based on a hemodynamic process. If there is a sexual stimulation in a male’s brain the signal is transmitted via the spinal cord. This process triggers the release of nitric oxide (NO) in the smooth muscle of the corpus cavernosum (the so-called erectile tissues) in a penis. NO activates guanylate cyclase. Then cyclic guanosine monophosphate (cGMP) is synthesized. The increased cGMP levels cause relaxation of smooth muscle, thereby increasing flows of blood to the penis. It comes to the erection.

The level of cGMP is regulated by the rate of synthesis of guanylate cyclase and the degradation rate of cGMP-hydrolyzing phosphodiesterase (PDE ferment). After using a PDE5 inhibitor its active compoenent increases the levels of cGMP by selectively inhibiting the degradation of cGMP by cGMP-specific ferment of PDE type 5 – recognized scientifically as the most important PDE in the penile corpus cavernosum. They act as competitive antagonists at the specific catalytic site of enzymes. All of three most common PDE5 inhibitors enhance the effect of endogenous NO released in response to proper sexual stimulation. This means that any chemical substances in PDE5 inhibitors without simultaneous won’t provide the desired effect.Erectile dysfunction

Erectile dysfunction remains a common problem of the male population. In the world of every sixth man is suffering from erectile dysfunction of varying severity. Among men who are older than 40 years the ED rate is even higher. Although erectile dysfunction is not a severe impairment of health, it can substantially impair the mental status of any man by significantly reducing the quality of life. In addition, a man with ED often develops anxiety and depression, increased anxiety and irritability. My Canadian Pharmacy www.mycanadianpharmacymall.com just proved to you that there are effective oral medications called PDE5 inhibitors actually capable of helping a person to cope with impotence episodes.

In addition to Generic Viagra, Levitra and Cialis, customers of My Canadian Pharmacy can also choose between top-notch generics of the popular and relatively new erectile dysfunction pills. Before making any choice we always give recommendations to our clients and guests to talk with their family therapists or third-party healthcare specialists to understand fully the reasons of their impotence cases. If you trust us with your health our Support Line is always open for people who want to get a free consultation before placing any order.